Effective date : FIELD: medicine. The produced polypeptide is used in treating a disease or a condition characterised by pathological activity of chemokine receptor. Many hormones, neurotransmitters, and biologically active substances control, regulate, or adjust the functions of living organisms through specific receptors located on cell membranes. Many of these receptors mediate the transmission of intracellular signals by activating guanine nucleotide binding proteins G proteins to which the receptor binds. The binding of a specific signaling molecule to GPCR can cause a change in the conformation of the receptor, resulting in a form capable of binding to and activating the G-protein, thereby initiating a cascade of intracellular events, which ultimately leads to a biological response. Typically, GPCRs interact with G-proteins to regulate the synthesis of intracellular secondary messengers such as cAMP, inositol phosphates, diacylglycerol and calcium ions. Chemokines are attractants for white blood cells and are involved in the immune processes associated with the migration of white blood cells.
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Results: Exact: 7. Elapsed time: 87 ms.
Results: Exact: 2. Elapsed time: 85 ms.
Chinese Trad. Select a language. Data that resides in persistent storage on physical media, in any digital format. This includes files on magnetic or optical media, archived data, and data backups. The Advanced eDiscovery feature that allows users to check the accuracy of the program's tagging from a user-defined point down to zero. The API that you can use from a device to send device-to-cloud messages to an IoT hub, and receive cloud-to-device messages from an IoT hub. The software development kit built for cloud-based client-server communication that facilitates connecting to and interacting with Azure services. Data that resides in persistent storage on physical media, in any digital format, in excess of a customer's commitment limit in the standard billing plan.