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The present invention relates to binding members, especially antibody molecules that inhibit the biological effects of IL Binding members are useful for treating diseases associated with IL-6, including inflammatory diseases and tumors. Interleukin 6 IL-6 is a 26 kDa pleiotropic pro-inflammatory cytokine produced by a number of cell types, including stimulated fibroblasts, monocytes and endothelial cells, which form the main source of IL-6 in vivo. Cells, such as T cells, B cells, macrophages, keratinocytes, osteoblasts and several others, can produce IL-6 upon stimulation.
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